Everything about Myelosuppression totally explained
Bone marrow suppression is a serious side-effect of
chemotherapy and certain drugs affecting the immune system such as
azathioprine.
NSAIDS may also cause bone marrow suppression. The risk is especially high in chemotherapy for
leukaemia.
Because the
bone marrow is the manufacturing center of blood cells, the suppression of bone marrow activity causes a deficiency of blood cells. This condition can rapidly lead to life-threatening
infection, as the body can't produce
leukocytes in response to invading
bacteria and
viruses, as well as lead to anaemia due to a lack of
red blood cells and spontaneous severe bleeding due to deficiency of
platelets.
Bone marrow suppression due to azathioprine can be treated by changing to another medication such as
mycophenolate mofetil (for organ transplants) or other disease-modifying drugs in
rheumatoid arthritis or
Crohn's disease. Bone marrow suppression due to anti-cancer chemotherapy is much harder to treat and often involves hospital admission, strict infection control, and aggressive use of intravenous
antibiotics at the first sign of infection.
Further Information
Get more info on 'Myelosuppression'.
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